- 联系人:李刚
- 电 话:021-64806089
- 手 机:17717618050
- 传 真:021-34536277
- 邮 箱:zllg@gh-reagent.com
- 地 址:闵行区沈杜公路3387号
起批量(瓶) | 价格 |
---|---|
≥1 | ¥1421.55元/瓶 |
- 供货能力:100
- 最低订购量:1瓶
- 可销售总数量:100瓶
- 建议零销价:1421.55元/瓶
- 发布日期: 2017-02-11
- 更新日期: 2018-07-19
cas编号: | 71963-77-4 | einecs编号: | |
别名: | oa;软海绵酸;35-去甲基鳍藻毒素 1 | 分子式: | cas号:78111-17-8 分子式:c44h68o13 |
含量≥: | 98 % | 产地/厂商: | 上海 |
产品英文名称: | okadaic acid |
ga60058
国华
冈田酸 cas:78111-凯发网站
98%英文名称:okadaic acidcas号:78111-17-8分子式:c44h68o13分子量:805einecs编号:mdl号:包装:100ug别名:oa;软海绵酸;35-去甲基鳍藻毒素 1收藏
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质检证书(coa)
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中文名称: | 冈田酸 |
中文别名: | oa;软海绵酸;35-去甲基鳍藻毒素 1 |
英文名称: | okadaic acid |
英文别名: | 35-demethyldinophysistoxin 1;okadaic acid |
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熔点: | c |
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溶解性: | soluble in ethanol (25 mg/ml), dmso (25 mg/ml), methanol (≥1 mg/ml), chloroform, acetone, ethyl acetate, dmf, and dimethylsulfoxide. insoluble in water |
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产品介绍: | okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, prorocentrium spp.. it is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: pp2a-c (pp2a) which is inhibited completely at 1 nm and pp1 which is inhibited at higher concentrations (ic50= 10-15 nm). pp2b is much less sensitive to okadaic acid than pp1, while pp2c is not inhibited. this selectivity is the basis for an improved identification and quantification procedure for these enzymes. the hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. it mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. okadaic acid is an activator of pkc. |
产品应用: | an activator of pkc and inhibitor of pp1 and pp2a phosphatases;okadaic acid is a potent non-tpatype tumor promoter and vasodilator. it induces hyperphosphorylation of the p53 oncoprotein |
生化机理: | dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. readily enters cells. inhibitor of type 1 and type 2a protein phosphatases. does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. known tumor promotor. used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. |
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个人防护设备: | eyeshields, faceshields, gloves, type p2 (en 143) respirator cartridges |
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储存条件: | 储存条件:-20°c |